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KMID : 0606320040200010037
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.20 No. 1 p.37 ~ p.41
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The Change on Brain Transport of Choline and Taurine by Aging
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Kang Young-Sook
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Abstract
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The blood-brain barrier (BBB) permeability of [3H]choline was compared in senescence-accelerated mouse(SAM) and normal mouse (ICR) with common carotid artery perfusion (CCAP) method to establish a possible relation between aging and changes in brain transport of choline and taurine. The SAM strains developed as the animal model show senescence acceleration and age-associated pathological phenotypes similar to geriatric disorders seen in humans. Futhermore choline plays a key role in function of biological membrane and as a precursor for the synthesis of acetylcholine related with Alzheimer’s disease or dementia. Taurine is also known to have a neuroprotective effect against oxidative stress and excito-toxic agents. As the result of the experiments, the brain volume of distribution (VD, brain) of [3H]Choline in SAM by CCAP method increased about 4-fold compared with that in normal mice while VD, brain of [3H]taurine in SAM was reduced by 85%. These results suggest that aging may bring about changes on the brain transport activity of choline and taurine through the BBB.
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